These methods emphasize the hydrophobic core and solvent-exposed DOPE . Statistical potentials are more computationally efficient than energy calculations.
2.
The idea is to consider statistical observations as heavenly bodies governed by a statistical potential energy which is zero only when an underlying statistical null hypothesis is true.
3.
Statistical potentials, in contrast to physics-based potentials, have the advantage of being fast to compute, of accounting implicitly of complex effects and being less sensitive to small changes in the protein structure.
4.
An alternative approach is to derive a knowledge-based statistical potential for interactions from a large database of protein-ligand complexes, such as the Protein Data Bank, and evaluate the fit of the pose according to this inferred potential.
5.
Statistical potentials are empirical methods based on observed residue-residue contact frequencies among proteins of known structure in the PDB . They assign a probability or energy score to each possible pairwise interaction between amino acids and combine these pairwise interaction scores into a single score for the entire model.
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